Cargando…

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

Tissue homeostasis is dependent on the controlled localization of specific cell types and the correct composition of the extracellular stroma. While the role of the cancer stroma in tumour progression has been well characterized, the specific contribution of the matrix itself is unknown. Furthermore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaukonen, Riina, Mai, Anja, Georgiadou, Maria, Saari, Markku, De Franceschi, Nicola, Betz, Timo, Sihto, Harri, Ventelä, Sami, Elo, Laura, Jokitalo, Eija, Westermarck, Jukka, Kellokumpu-Lehtinen, Pirkko-Liisa, Joensuu, Heikki, Grenman, Reidar, Ivaska, Johanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976218/ https://www.ncbi.nlm.nih.gov/pubmed/27488962 http://dx.doi.org/10.1038/ncomms12237

Ejemplares similares

Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma
por: Routila, Johannes, et al.
Publicado: (2021)

Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy
por: Bychkov, Dmitrii, et al.
Publicado: (2021)

Outcome and biomarker supervised deep learning for survival prediction in two multicenter breast cancer series
por: Bychkov, Dmitrii, et al.
Publicado: (2022)

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
por: Jacquemet, Guillaume, et al.
Publicado: (2016)

Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry
por: Wirtz, Ralph M., et al.
Publicado: (2016)

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
por: Sihto, Harri, et al.
Publicado: (2012)

CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance
por: Ventelä, Sami, et al.
Publicado: (2014)

The past and present of prostate cancer and its treatment and diagnostics: A historical review
por: Lehtonen, Miikka, et al.
Publicado: (2023)

ERBB4 Promoter Polymorphism Is Associated with Poor Distant Disease-Free Survival in High-Risk Early Breast Cancer
por: Kurppa, Kari J., et al.
Publicado: (2014)

Changes in attitudes towards hastened death among Finnish physicians over the past sixteen years
por: Piili, Reetta P., et al.
Publicado: (2018)

Physicians’ decreased tendency to choose palliative care for patients with advanced dementia between 1999 and 2015
por: Haapasalmi, Saila, et al.
Publicado: (2021)

Transient Changes in Serum CEA, CA19-9, CRP, YKL-40, and IL-6 during Adjuvant Chemotherapy and Survival of Patients with Colorectal Cancer
por: Lehtomäki, Kaisa, et al.
Publicado: (2023)

Lead Time and Prognostic Role of Serum CEA, CA19-9, IL-6, CRP, and YKL-40 after Adjuvant Chemotherapy in Colorectal Cancer
por: Lehtomäki, Kaisa, et al.
Publicado: (2021)

Undergraduate curriculum in palliative medicine at Tampere University increases students’ knowledge
por: Lehto, Juho T., et al.
Publicado: (2017)

Both comorbidity and worse performance status are associated with poorer overall survival after external beam radiotherapy for prostate cancer
por: Lehtonen, Miikka, et al.
Publicado: (2020)

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells
por: Muharram, Ghaffar, et al.
Publicado: (2014)

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells
por: Muharram, Ghaffar, et al.
Publicado: (2014)

Transcripts of the Prostate Cancer-Associated Gene ANO7 Are Retained in the Nuclei of Prostatic Epithelial Cells
por: Metsälä, Olli, et al.
Publicado: (2023)

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
por: Närvä, Elisa, et al.
Publicado: (2022)

Somatic Mutation Profiling and Associations With Prognosis and Trastuzumab Benefit in Early Breast Cancer
por: Loi, Sherene, et al.
Publicado: (2013)

Evaluation of prognostic biomarkers in a population-validated Finnish HNSCC patient cohort
por: Routila, J., et al.
Publicado: (2021)

Local and systemic oxidant/antioxidant status before and during lung cancer radiotherapy
por: Crohns, Marika, et al.
Publicado: (2009)

SORLA regulates endosomal trafficking and oncogenic fitness of HER2
por: Pietilä, Mika, et al.
Publicado: (2019)

Troponin T-release associates with cardiac radiation doses during adjuvant left-sided breast cancer radiotherapy
por: Skyttä, Tanja, et al.
Publicado: (2015)

Treatment accuracy without rotational setup corrections in intracranial SRT
por: Boman, Eeva, et al.
Publicado: (2016)

Does special education in palliative medicine make a difference in end-of-life decision-making?
por: Piili, Reetta P., et al.
Publicado: (2018)

Dynamic Contrast-Enhanced Imaging as a Prognostic Tool in Early Diagnosis of Prostate Cancer: Correlation with PSA and Clinical Stage
por: Wu, Xingchen, et al.
Publicado: (2018)

Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma
por: Terävä, Joonas, et al.
Publicado: (2019)

Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer
por: Lehto, Ulla-Sisko, et al.
Publicado: (2018)

Human breast cancer cells educate macrophages toward the M2 activation status
por: Sousa, Sofia, et al.
Publicado: (2015)

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers
por: Ventelä, Sami, et al.
Publicado: (2016)

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability
por: Jacquemet, Guillaume, et al.
Publicado: (2019)

The Novel Protease Activities of JMJD5–JMJD6–JMJD7 and Arginine Methylation Activities of Arginine Methyltransferases Are Likely Coupled
por: Liu, Haolin, et al.
Publicado: (2022)

Estimation of adequate setup margins and threshold for position errors requiring immediate attention in head and neck cancer radiotherapy based on 2D image guidance
por: Kapanen, Mika, et al.
Publicado: (2013)

Correlations between Functional Imaging Markers Derived from PET/CT and Diffusion-Weighted MRI in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
por: Wu, Xingchen, et al.
Publicado: (2014)

Determination of the optimal matching position for setup images and minimal setup margins in adjuvant radiotherapy of breast and lymph nodes treated in voluntary deep inhalation breath-hold
por: Laaksomaa, Marko, et al.
Publicado: (2015)

Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7
por: Liu, Haolin, et al.
Publicado: (2018)

3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography
por: Tuohinen, Suvi Sirkku, et al.
Publicado: (2021)

Expression of KIT Receptor Tyrosine Kinase in Endothelial Cells of Juvenile Brain Tumors
por: Puputti, Marjut, et al.
Publicado: (2009)

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours
por: Pulkka, Olli‐Pekka, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d1hd05pede87hodem56p46p113