Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL

The function of monoacylglycerol lipase (MGL), a key actor in the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2AG), is tightly controlled by the cell’s redox state: oxidative signals such as hydrogen peroxide suppress MGL activity in a reversible manner through sulfeny...

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Detalles Bibliográficos
Autores principales: Scalvini, Laura, Vacondio, Federica, Bassi, Michele, Pala, Daniele, Lodola, Alessio, Rivara, Silvia, Jung, Kwang-Mook, Piomelli, Daniele, Mor, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976315/
https://www.ncbi.nlm.nih.gov/pubmed/27499063
http://dx.doi.org/10.1038/srep31046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976315/
https://www.ncbi.nlm.nih.gov/pubmed/27499063
http://dx.doi.org/10.1038/srep31046

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