A subpopulation of high IL-21-producing CD4(+) T cells in Peyer’s Patches is induced by the microbiota and regulates germinal centers

The production of IL-21 by T follicular helper (Tfh) cells is vital in driving the germinal centre reaction and high affinity antibody formation. However, the degree of Tfh cell heterogeneity and function is not fully understood. We used a novel IL-21eGFP reporter mouse strain to analyze the diversi...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Leigh, Ho, Wen Qi, Ying, Sze, Ramakrishna, Lakshmi, Srinivasan, Kandhadayar G., Yurieva, Marina, Ng, Wan Pei, Subramaniam, Sharrada, Hamadee, Nur H., Joseph, Sabrina, Dolpady, Jayashree, Atarashi, Koji, Honda, Kenya, Zolezzi, Francesca, Poidinger, Michael, Lafaille, Juan J., Curotto de Lafaille, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976330/
https://www.ncbi.nlm.nih.gov/pubmed/27499025
http://dx.doi.org/10.1038/srep30784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976330/
https://www.ncbi.nlm.nih.gov/pubmed/27499025
http://dx.doi.org/10.1038/srep30784

Ejemplares similares