AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation

Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the scaffold protein AMBRA1...

Descripción completa

Detalles Bibliográficos
Autores principales: Cianfanelli, Valentina, Fuoco, Claudia, Lorente, Mar, Salazar, Maria, Quondamatteo, Fabio, Gherardini, Pier Federico, De Zio, Daniela, Nazio, Francesca, Antonioli, Manuela, D’Orazio, Melania, Skobo, Tatjana, Bordi, Matteo, Rohde, Mikkel, Dalla Valle, Luisa, Helmer-Citterich, Manuela, Gretzmeier, Christine, Dengjel, Joern, Fimia, Gian Maria, Piacentini, Mauro, Di Bartolomeo, Sabrina, Velasco, Guillermo, Cecconi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976803/
https://www.ncbi.nlm.nih.gov/pubmed/25438055
http://dx.doi.org/10.1038/ncb3072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976803/
https://www.ncbi.nlm.nih.gov/pubmed/25438055
http://dx.doi.org/10.1038/ncb3072

Ejemplares similares