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Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches
Rosmarinic acid (RA) possesses several protective bioactivities that have attracted increasing interest by nutraceutical/pharmaceutical industries. Considering the reduced bioavailability after oral use, effective (and safe) delivery systems are crucial to protect RA from gastrointestinal degradatio...
Autores principales: | Madureira, Ana Raquel, Nunes, Sara, Campos, Débora A, Fernandes, João C, Marques, Cláudia, Zuzarte, Monica, Gullón, Beatriz, Rodríguez-Alcalá, Luís M, Calhau, Conceição, Sarmento, Bruno, Gomes, Ana Maria, Pintado, Maria Manuela, Reis, Flávio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977102/ https://www.ncbi.nlm.nih.gov/pubmed/27536103 http://dx.doi.org/10.2147/IJN.S104623 |
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