Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate

Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of thi...

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Detalles Bibliográficos
Autores principales: Kong, Ling-Lei, Shen, Guo-Lin, Wang, Zhi-Yuan, Zhuang, Xiao-Mei, Xiao, Wei-Bin, Yuan, Mei, Gong, Ze-Hui, Li, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977286/
https://www.ncbi.nlm.nih.gov/pubmed/27555820
http://dx.doi.org/10.3389/fphar.2016.00242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977286/
https://www.ncbi.nlm.nih.gov/pubmed/27555820
http://dx.doi.org/10.3389/fphar.2016.00242

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