Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions

Voltage-gated K(+) (Kv) channel activation depends on interactions between voltage sensors and an intracellular activation gate that controls access to a central pore cavity. Here, we hypothesize that this gate is additionally responsible for closed-state inactivation (CSI) in Kv4.x channels. These...

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Detalles Bibliográficos
Autores principales: Fineberg, Jeffrey D., Szanto, Tibor G., Panyi, Gyorgy, Covarrubias, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977472/
https://www.ncbi.nlm.nih.gov/pubmed/27502553
http://dx.doi.org/10.1038/srep31131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977472/
https://www.ncbi.nlm.nih.gov/pubmed/27502553
http://dx.doi.org/10.1038/srep31131

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