Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression

We previously found that the scaffold adapter GRB2-associated binding protein 2 (GAB2) is amplified and overexpressed in a subset of primary high-grade serous ovarian cancers and cell lines. Ovarian cancer cells overexpressing GAB2 are dependent on GAB2 for activation of the phosphatidylinositol 3-k...

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Detalles Bibliográficos
Autores principales: Duckworth, C, Zhang, L, Carroll, S L, Ethier, S P, Cheung, H W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977484/
https://www.ncbi.nlm.nih.gov/pubmed/26657155
http://dx.doi.org/10.1038/onc.2015.472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977484/
https://www.ncbi.nlm.nih.gov/pubmed/26657155
http://dx.doi.org/10.1038/onc.2015.472

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