A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence

DNA methylation in a CpG context can be recognised by methyl-CpG binding protein 2 (MeCP2) via its methyl-CpG binding domain (MBD). An A/T run next to a methyl-CpG maximises the binding of MeCP2 to the methylated DNA. The A/T run characteristics are reported here with an X-ray structure of MBD A140V...

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Detalles Bibliográficos
Autores principales: Chia, Jyh Yea, Tan, Wen Siang, Ng, Chyan Leong, Hu, Nien-Jen, Foo, Hooi Ling, Ho, Kok Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977486/
https://www.ncbi.nlm.nih.gov/pubmed/27502833
http://dx.doi.org/10.1038/srep31210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977486/
https://www.ncbi.nlm.nih.gov/pubmed/27502833
http://dx.doi.org/10.1038/srep31210

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