Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases

Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3)...

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Detalles Bibliográficos
Autores principales: Jang, Tae-Ho, Lim, In-Hye, Kim, Chang Min, Choi, Jae Young, Kim, Eun-Ae, Lee, Tae-Jin, Park, Hyun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977500/
https://www.ncbi.nlm.nih.gov/pubmed/27502430
http://dx.doi.org/10.1038/srep31198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977500/
https://www.ncbi.nlm.nih.gov/pubmed/27502430
http://dx.doi.org/10.1038/srep31198

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