Echinocandin B biosynthesis: a biosynthetic cluster from Aspergillus nidulans NRRL 8112 and reassembly of the subclusters Ecd and Hty from Aspergillus pachycristatus NRRL 11440 reveals a single coherent gene cluster

BACKGROUND: Echinocandins are nonribosomal lipopeptides produced by ascommycete fungi. Due to their strong inhibitory effect on fungal cell wall biosynthesis and lack of human toxicity, they have been developed to an important class of antifungal drugs. Since 2012, the biosynthetic gene clusters of...

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Detalles Bibliográficos
Autores principales: Hüttel, Wolfgang, Youssar, Loubna, Grüning, Björn A., Günther, Stefan, Hugentobler, Katharina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977696/
https://www.ncbi.nlm.nih.gov/pubmed/27502607
http://dx.doi.org/10.1186/s12864-016-2885-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977696/
https://www.ncbi.nlm.nih.gov/pubmed/27502607
http://dx.doi.org/10.1186/s12864-016-2885-x

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