Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding

BACKGROUND: Transport across the blood–brain barrier (BBB) is an important mediator of beta-amyloid (Aβ) accumulation in the brain and a contributing factor in the pathogenesis of Alzheimer’s disease (AD). One of the receptors responsible for the transport of Aβ in the BBB is the low density lipopro...

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Detalles Bibliográficos
Autores principales: Shackleton, B., Crawford, F., Bachmeier, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977753/
https://www.ncbi.nlm.nih.gov/pubmed/27503326
http://dx.doi.org/10.1186/s12987-016-0038-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977753/
https://www.ncbi.nlm.nih.gov/pubmed/27503326
http://dx.doi.org/10.1186/s12987-016-0038-x

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