Cargando…

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes

Pathological inclusions containing aggregated, highly phosphorylated (at serine129) α-synuclein (αS pSer129) are characteristic of a group of neurodegenerative diseases termed synucleinopathies. Antibodies to the pSer129 epitope can be highly sensitive in detecting αS inclusions in human tissue and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rutherford, Nicola J., Brooks, Mieu, Giasson, Benoit I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977832/ https://www.ncbi.nlm.nih.gov/pubmed/27503460 http://dx.doi.org/10.1186/s40478-016-0357-9

Ejemplares similares

Pramipexole Reduces Phosphorylation of α-Synuclein at Serine-129
por: Chau, Kai-Yin, et al.
Publicado: (2013)

α-Synuclein serine129 phosphorylation – the physiology of pathology
por: Ramalingam, Nagendran, et al.
Publicado: (2023)

In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129
por: Weston, Leah J., et al.
Publicado: (2021)

CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation
por: Elsholz, Lea, et al.
Publicado: (2021)

Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties
por: Dent, Sydney E., et al.
Publicado: (2021)

Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein
por: Elfarrash, Sara, et al.
Publicado: (2021)

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
por: Inglis, Kelly J., et al.
Publicado: (2009)

Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases
por: Fayyad, Muneera, et al.
Publicado: (2020)

Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2
por: Sano, Kazunori, et al.
Publicado: (2021)

Serine 129 Phosphorylation of α-Synuclein Cross-Links with Tissue Transglutaminase to Form Lewy Body-Like Inclusion Bodies
por: Bi, Wei, et al.
Publicado: (2011)

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity
por: Ghanem, Simona S., et al.
Publicado: (2022)

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo
por: Lou, Haiyan, et al.
Publicado: (2010)

Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies
por: Weston, Leah J., et al.
Publicado: (2021)

Characterization of a Novel Monoclonal Antibody for Serine-129 Phosphorylated α-Synuclein: A Potential Application for Clinical and Basic Research
por: Liu, Weijin, et al.
Publicado: (2022)

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease
por: Kleinknecht, Alexandra, et al.
Publicado: (2016)

PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive early breast cancer
por: Ishida, Naoko, et al.
Publicado: (2018)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
por: Sorrentino, Zachary A., et al.
Publicado: (2017)

Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein–coupled receptor kinase–dependent manner
por: Hara, Susumu, et al.
Publicado: (2013)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
por: Rutherford, Nicola J., et al.
Publicado: (2015)

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets
por: Moore, Samantha F., et al.
Publicado: (2011)

Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts
por: Fiske, Michael, et al.
Publicado: (2011)

Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice
por: Domenicale, Chiara, et al.
Publicado: (2022)

Evolutionary patterns of phosphorylated serines
por: Kurmangaliyev, Yerbol Z, et al.
Publicado: (2011)

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
por: Longo, Francesco, et al.
Publicado: (2017)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

Hunting for Serine 276-Phosphorylated p65
por: Spooren, Anneleen, et al.
Publicado: (2010)

Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization
por: Tang, Xiaoli, et al.
Publicado: (2010)

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
por: Arawaka, Shigeki, et al.
Publicado: (2017)

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
por: Ramalingam, Nagendran, et al.
Publicado: (2023)

Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae
por: Bun, Jessica S., et al.
Publicado: (2020)

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo
por: McWilliams, Thomas G., et al.
Publicado: (2018)

Phosphorylation of Serine 114 on Atg32 mediates mitophagy
por: Aoki, Yoshimasa, et al.
Publicado: (2011)

Screening for serine/threonine kinases phosphorylating Stat5
por: Berger, Angelika, et al.
Publicado: (2011)

Phosphorylation at serine 331 is required for Aurora B activation
por: Petsalaki, Eleni, et al.
Publicado: (2011)

Mechanism of Ribonuclease III Catalytic Regulation by Serine Phosphorylation
por: Gone, Swapna, et al.
Publicado: (2016)

Regulation of divalent metal transporter-1 by serine phosphorylation
por: Seo, Young Ah, et al.
Publicado: (2016)

Androgen Receptor Phosphorylation at Serine 308 and Serine 791 Predicts Enhanced Survival in Castrate Resistant Prostate Cancer Patients
por: McCall, Pamela, et al.
Publicado: (2013)

Serine phosphorylation regulates paxillin turnover during cell migration
por: Abou Zeid, Nancy, et al.
Publicado: (2006)

The Serine 814 of TRPC6 Is Phosphorylated under Unstimulated Conditions
por: Bousquet, Simon M., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_e2ukrvemgcmf0lrjgsuuqsnsjg