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An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

The healthy lung maintains a steady state of immune readiness to rapidly respond to injury from invaders. Integrins are important for setting the parameters of this resting state, particularly the epithelial-restricted αVβ6 integrin, which is upregulated during injury. Once expressed, αVβ6 moderates...

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Detalles Bibliográficos
Autores principales: Meliopoulos, Victoria A., Van de Velde, Lee-Ann, Van de Velde, Nicholas C., Karlsson, Erik A., Neale, Geoff, Vogel, Peter, Guy, Cliff, Sharma, Shalini, Duan, Susu, Surman, Sherri L., Jones, Bart G., Johnson, Michael D. L., Bosio, Catharine, Jolly, Lisa, Jenkins, R. Gisli, Hurwitz, Julia L., Rosch, Jason W., Sheppard, Dean, Thomas, Paul G., Murray, Peter J., Schultz-Cherry, Stacey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978498/
https://www.ncbi.nlm.nih.gov/pubmed/27505057
http://dx.doi.org/10.1371/journal.ppat.1005804