The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals

Myosins play essential roles in the development and function of auditory organs and multiple myosin genes are associated with hereditary forms of deafness. Using a forward genetic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essential gene for auditory organ development. Ubr3 negati...

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Detalles Bibliográficos
Autores principales: Li, Tongchao, Giagtzoglou, Nikolaos, Eberl, Daniel F, Jaiswal, Sonal Nagarkar, Cai, Tiantian, Godt, Dorothea, Groves, Andrew K, Bellen, Hugo J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978524/
https://www.ncbi.nlm.nih.gov/pubmed/27331610
http://dx.doi.org/10.7554/eLife.15258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978524/
https://www.ncbi.nlm.nih.gov/pubmed/27331610
http://dx.doi.org/10.7554/eLife.15258

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