Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in vivo significance of this regulation. We stud...

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Detalles Bibliográficos
Autores principales: Solana, Jordi, Irimia, Manuel, Ayoub, Salah, Orejuela, Marta Rodriguez, Zywitza, Vera, Jens, Marvin, Tapial, Javier, Ray, Debashish, Morris, Quaid, Hughes, Timothy R, Blencowe, Benjamin J, Rajewsky, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978528/
https://www.ncbi.nlm.nih.gov/pubmed/27502555
http://dx.doi.org/10.7554/eLife.16797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978528/
https://www.ncbi.nlm.nih.gov/pubmed/27502555
http://dx.doi.org/10.7554/eLife.16797

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