Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation

Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1...

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Detalles Bibliográficos
Autores principales: Johmura, Yoshikazu, Yamashita, Emiri, Shimada, Midori, Nakanishi, Keiko, Nakanishi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979019/
https://www.ncbi.nlm.nih.gov/pubmed/27507734
http://dx.doi.org/10.1038/srep31194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979019/
https://www.ncbi.nlm.nih.gov/pubmed/27507734
http://dx.doi.org/10.1038/srep31194

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