Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy

Combination therapy with α-CTLA-4 and α-PD-1 has shown significant clinical responses in different types of cancer. However, the underlying mechanisms remain elusive. Here, combining detailed analysis of human tumour samples with preclinical tumour models, we report that concomitant blockade of CTLA...

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Detalles Bibliográficos
Autores principales: Shi, Lewis Zhichang, Fu, Tihui, Guan, Baoxiang, Chen, Jianfeng, Blando, Jorge M., Allison, James P., Xiong, Liangwen, Subudhi, Sumit K., Gao, Jianjun, Sharma, Padmanee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979067/
https://www.ncbi.nlm.nih.gov/pubmed/27498556
http://dx.doi.org/10.1038/ncomms12335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979067/
https://www.ncbi.nlm.nih.gov/pubmed/27498556
http://dx.doi.org/10.1038/ncomms12335

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