CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells

BACKGROUND: Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Zhou, Peng, Fan, Fan, Li, Dan, Wu, Jihong, Lu, Yi, Luo, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979130/
https://www.ncbi.nlm.nih.gov/pubmed/27507241
http://dx.doi.org/10.1186/s12886-016-0309-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979130/
https://www.ncbi.nlm.nih.gov/pubmed/27507241
http://dx.doi.org/10.1186/s12886-016-0309-y

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