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CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells

BACKGROUND: Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression...

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Detalles Bibliográficos
Autores principales:	Liu, Xin, Zhou, Peng, Fan, Fan, Li, Dan, Wu, Jihong, Lu, Yi, Luo, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979130/ https://www.ncbi.nlm.nih.gov/pubmed/27507241 http://dx.doi.org/10.1186/s12886-016-0309-y

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