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Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway

Helicobacter pylori (H. pylori) produces vacuolating cytotoxin (VacA), a potent protein toxin, which is associated with gastric inflammation and ulceration. Recent studies demonstrated that connexins (Cxs), which are responsible for intracellular communication at gap junctions (GJs) as well as cell...

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Detalles Bibliográficos
Autores principales: Yahiro, K, Akazawa, Y, Nakano, M, Suzuki, H, Hisatune, J, Isomoto, H, Sap, J, Noda, M, Moss, J, Hirayama, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979424/
https://www.ncbi.nlm.nih.gov/pubmed/27551466
http://dx.doi.org/10.1038/cddiscovery.2015.35