Cargando…

Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway

Helicobacter pylori (H. pylori) produces vacuolating cytotoxin (VacA), a potent protein toxin, which is associated with gastric inflammation and ulceration. Recent studies demonstrated that connexins (Cxs), which are responsible for intracellular communication at gap junctions (GJs) as well as cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yahiro, K, Akazawa, Y, Nakano, M, Suzuki, H, Hisatune, J, Isomoto, H, Sap, J, Noda, M, Moss, J, Hirayama, T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979424/ https://www.ncbi.nlm.nih.gov/pubmed/27551466 http://dx.doi.org/10.1038/cddiscovery.2015.35

Ejemplares similares

Helicobacter pylori VacA toxin causes cell death by inducing accumulation of cytoplasmic connexin 43
por: Yahiro, K, et al.
Publicado: (2015)

New Insights into VacA Intoxication Mediated through Its Cell Surface Receptors
por: Yahiro, Kinnosuke, et al.
Publicado: (2016)

Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis
por: Akazawa, Yuko, et al.
Publicado: (2013)

Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521
por: Nakano, Masayuki, et al.
Publicado: (2016)

An Overview of Helicobacter pylori VacA Toxin Biology
por: Foegeding, Nora J., et al.
Publicado: (2016)

Diversification of the vacAs1m1 and vacAs2m2 Strains of Helicobacter pylori in Meriones unguiculatus
por: Mendoza-Elizalde, Sandra, et al.
Publicado: (2016)

VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets
por: Satoh, Kaneo, et al.
Publicado: (2013)

Immunosuppressive and Proinflammatory Activities of the VacA Toxin of Helicobacter pylori
por: Montecucco, Cesare, et al.
Publicado: (2003)

Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway
por: Zhu, Pan, et al.
Publicado: (2017)

Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA
por: Gupta, Vijay R., et al.
Publicado: (2008)

Prevalence of Helicobacter pylori vacA different genotypes in Isfahan, Iran
por: Havaei, S. Asghar, et al.
Publicado: (2014)

Expression and Antigenic Evaluation of VacA Antigenic Fragment of Helicobacter Pylori
por: Hasanzadeh, Leila, et al.
Publicado: (2013)

VacA’s Induction of VacA-Containing Vacuoles (VCVs) and Their Immunomodulatory Activities on Human T Cells
por: Utsch, Ciara, et al.
Publicado: (2016)

Helicobacter pylori cagA and vacA genes in dyspeptic Ghanaian patients
por: Archampong, Timothy N., et al.
Publicado: (2017)

Treatment with Helicobacter pylori-derived VacA attenuates allergic airway disease
por: Reuter, Sebastian, et al.
Publicado: (2023)

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms
por: Chatre, Laurent, et al.
Publicado: (2017)

A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori–Induced Metaplasia in the Stomach
por: Winter, Jody A., et al.
Publicado: (2014)

Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA
por: Molinari, Maurizio, et al.
Publicado: (1998)

The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk
por: Backert, Steffen, et al.
Publicado: (2010)

Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis
por: Palframan, Samuel L., et al.
Publicado: (2012)

Inhibitory Effects of Anthocyanins on Secretion of Helicobacter pylori CagA and VacA Toxins
por: Kim, Sa-Hyun, et al.
Publicado: (2012)

vacA Genotype Status of Helicobacter pylori Isolated from Foods with Animal Origin
por: Saeidi, Elnaz, et al.
Publicado: (2016)

Serum VEGF Levels in Helicobacter pylori Infection and Correlation with Helicobacter pylori cagA and vacA Genes
por: Siregar, Gontar, et al.
Publicado: (2017)

Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA
por: Link, Alexander, et al.
Publicado: (2017)

DNA Sequence Analysis of South African Helicobacter pylori Vacuolating Cytotoxin Gene (vacA)
por: Tanih, Nicoline F., et al.
Publicado: (2011)

Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA)
por: Kim, Ik-Jung, et al.
Publicado: (2012)

Characterization of virulence genes cagA and vacA in Helicobacter Pylori and their prevalence in gastrointestinal disorders
por: Cogo, Laura Lúcia, et al.
Publicado: (2011)

Relevance of vacA Genotypes of Helicobacter pylori to cagA Status and Its Clinical Outcome
por: Park, Sill Moo, et al.
Publicado: (2001)

New genotypes of Helicobacter Pylori VacA d-region identified from global strains
por: Soyfoo, Djaleel Muhammad, et al.
Publicado: (2021)

Genotyping of Helicobacter pylori Virulence Genes cagA and vacA: Regional and National Study
por: Kishk, Rania M., et al.
Publicado: (2021)

Evaluating CagA and VacA Oncoproteins of Helicobacter pylori in Oral Potentially Malignant Disorders
por: Sekar, Ramya, et al.
Publicado: (2021)

Response to ‘Helicobacter pylori infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation’
por: Nakano, Masayuki, et al.
Publicado: (2017)

Use of VacA as a Vaccine Antigen
por: Moyat, Mati, et al.
Publicado: (2016)

High Diversity of vacA and cagA Helicobacter pylori Genotypes in Patients with and without Gastric Cancer
por: López-Vidal, Yolanda, et al.
Publicado: (2008)

Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly
por: Cover, Timothy L., et al.
Publicado: (1997)

cagA and vacA in strains of Helicobacter pylori from ulcer and non-ulcerative dyspepsia patients
por: Faundez, Gustavo, et al.
Publicado: (2002)

Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes and correlation with clinical outcome
por: WEI, GUO-CHAO, et al.
Publicado: (2012)

Association between Helicobacter pylori, cagA, and vacA Status and Clinical Presentation in Iranian Children
por: Rafeey, Mandana, et al.
Publicado: (2013)

A systematic review on the association between the Helicobacter pylori vacA i genotype and gastric disease
por: Liu, Xian, et al.
Publicado: (2016)

Helicobacter pylori vacA Genotypes in Chronic Gastritis and Gastric Carcinoma Patients from Macau, China
por: Pinto-Ribeiro, Ines, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_h9ruh3m1pufot95i2g2vgg0262