An epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers

Epithelial–mesenchymal transition (EMT), a crucial mechanism in development, mediates aggressiveness during carcinoma progression and therapeutic refractoriness. The reversibility of EMT makes it an attractive strategy in designing novel therapeutic approaches. Therefore, drug discovery pipelines fo...

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Detalles Bibliográficos
Autores principales: Tang, H M, Kuay, K T, Koh, P F, Asad, M, Tan, T Z, Chung, V Y, Lee, S C, Thiery, J P, Huang, RY-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979427/
https://www.ncbi.nlm.nih.gov/pubmed/27551531
http://dx.doi.org/10.1038/cddiscovery.2016.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979427/
https://www.ncbi.nlm.nih.gov/pubmed/27551531
http://dx.doi.org/10.1038/cddiscovery.2016.41

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