Human pregnane X receptor compromises the function of p53 and promotes malignant transformation

The pregnane X receptor (PXR) is well established as a nuclear receptor that has a central role in xenobiotic metabolism and disposition. However, emerging evidence suggests that PXR is also a regulator of apoptosis, promoting a malignant phenotype both in vitro and in vivo. The tumor suppressor p53...

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Detalles Bibliográficos
Autores principales: Robbins, D, Cherian, M, Wu, J, Chen, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979430/
https://www.ncbi.nlm.nih.gov/pubmed/27547448
http://dx.doi.org/10.1038/cddiscovery.2016.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979430/
https://www.ncbi.nlm.nih.gov/pubmed/27547448
http://dx.doi.org/10.1038/cddiscovery.2016.23

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