ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1

Amyotrophic lateral sclerosis (ALS) is characterised by the formation of intracellular misfolded protein inclusions that form in motor neurons. Autophagy is the major degradation pathway for aggregate-prone proteins within lysosomes. Autophagy begins by the production of the omegasome, forming the a...

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Detalles Bibliográficos
Autores principales: Soo, K Y, Sultana, J, King, AE, Atkinson, RAK, Warraich, S T, Sundaramoorthy, V, Blair, I, Farg, M A, Atkin, J D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979432/
https://www.ncbi.nlm.nih.gov/pubmed/27551461
http://dx.doi.org/10.1038/cddiscovery.2015.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979432/
https://www.ncbi.nlm.nih.gov/pubmed/27551461
http://dx.doi.org/10.1038/cddiscovery.2015.30

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