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ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1
Amyotrophic lateral sclerosis (ALS) is characterised by the formation of intracellular misfolded protein inclusions that form in motor neurons. Autophagy is the major degradation pathway for aggregate-prone proteins within lysosomes. Autophagy begins by the production of the omegasome, forming the a...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979432/ https://www.ncbi.nlm.nih.gov/pubmed/27551461 http://dx.doi.org/10.1038/cddiscovery.2015.30 |