Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations

Retinitis pigmentosa (RP), an inherited blinding disease, is caused by a variety of different mutations that affect retinal photoreceptor function and survival. So far there is neither effective treatment nor cure. We have previously shown that poly(ADP-ribose)polymerase (PARP) acts as a common and...

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Detalles Bibliográficos
Autores principales: Jiao, K, Sahaboglu, A, Zrenner, E, Ueffing, M, Ekström, P A R, Paquet-Durand, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979439/
https://www.ncbi.nlm.nih.gov/pubmed/27551530
http://dx.doi.org/10.1038/cddiscovery.2016.40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979439/
https://www.ncbi.nlm.nih.gov/pubmed/27551530
http://dx.doi.org/10.1038/cddiscovery.2016.40

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