BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes

Heterozygous loss-of-function mutations in the hepatocyte nuclear factor 1α (HNF-1α) gene can lead to diminished amounts of functional HNF-1α, resulting in the onset of a particularly severe form of maturity-onset diabetes of the young (MODY). We have previously shown that induction of a dominant-ne...

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Detalles Bibliográficos
Autores principales: Pfeiffer, S, Halang, L, Düssmann, H, Byrne, MM, Prehn, JHM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979461/
https://www.ncbi.nlm.nih.gov/pubmed/27551471
http://dx.doi.org/10.1038/cddiscovery.2015.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979461/
https://www.ncbi.nlm.nih.gov/pubmed/27551471
http://dx.doi.org/10.1038/cddiscovery.2015.41

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