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Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes
The release of cathepsin proteases from disrupted lysosomes results in lethal cellular autodigestion. Lysosomal disruption-related cell death is highly variable, showing both apoptotic and necrotic outcomes. As the substrate spectrum of lysosomal proteases encompasses the apoptosis-regulating protei...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979493/ https://www.ncbi.nlm.nih.gov/pubmed/27551506 http://dx.doi.org/10.1038/cddiscovery.2016.12 |