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Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis
The ING1b protein is a type-II tumour suppressor and stoichiometric member of the Sin3 histone deacetylase (HDAC) protein complex in which it acts to target HDAC activity to regulate chromatin structure. Altering ING1 levels by ectopic expression of ING1b in cancer cells promotes apoptosis, whereas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979497/ https://www.ncbi.nlm.nih.gov/pubmed/27551477 http://dx.doi.org/10.1038/cddiscovery.2015.48 |