Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death

The mammalian target of rapamycin complex 1 (mTORC1) is a highly conserved protein complex regulating key pathways in cell growth. Hyperactivation of mTORC1 is implicated in numerous cancers, thus making it a potential broad-spectrum chemotherapeutic target. Here, we characterized how mTORC1 respond...

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Detalles Bibliográficos
Autores principales: Martin, R, Desponds, C, Eren, R O, Quadroni, M, Thome, M, Fasel, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979510/
https://www.ncbi.nlm.nih.gov/pubmed/27551516
http://dx.doi.org/10.1038/cddiscovery.2016.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979510/
https://www.ncbi.nlm.nih.gov/pubmed/27551516
http://dx.doi.org/10.1038/cddiscovery.2016.24

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