Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease

Expanding on a quinazoline scaffold, we developed tricyclic compounds with biological activity. These compounds bind to the 18 kDa translocator protein (TSPO) and protect U118MG (glioblastoma cell line of glial origin) cells from glutamate-induced cell death. Fascinating, they can induce neuronal di...

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Detalles Bibliográficos
Autores principales: Vainshtein, A, Veenman, L, Shterenberg, A, Singh, S, Masarwa, A, Dutta, B, Island, B, Tsoglin, E, Levin, E, Leschiner, S, Maniv, I, Pe’er, L, Otradnov, I, Zubedat, S, Aga-Mizrachi, S, Weizman, A, Avital, A, Marek, I, Gavish, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979516/
https://www.ncbi.nlm.nih.gov/pubmed/27551459
http://dx.doi.org/10.1038/cddiscovery.2015.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979516/
https://www.ncbi.nlm.nih.gov/pubmed/27551459
http://dx.doi.org/10.1038/cddiscovery.2015.27

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