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The Global Self-Reactivity Profile of the Natural Antibody Repertoire Is Largely Independent of Germline D(H) Sequence
Natural antibodies (NAbs) are produced in the absence of exogenous antigenic stimulation and circulate in the blood of normal, healthy individuals. These antibodies have been shown to provide one of the first lines of defense against both bacterial and viral pathogens. Conservation of the NAb repert...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979587/ https://www.ncbi.nlm.nih.gov/pubmed/27559334 http://dx.doi.org/10.3389/fimmu.2016.00296 |