Total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity

The first total synthesis of leopolic acid A, a fungal metabolite with a rare 2,3-pyrrolidinedione nucleus linked to an ureido dipeptide, was designed and carried out. Crucial steps for the strategy include a Dieckmann cyclization to obtain the 2,3-pyrrolidinedione ring and a Wittig olefination to i...

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Detalles Bibliográficos
Autores principales: Dhavan, Atul A, Kaduskar, Rahul D, Musso, Loana, Scaglioni, Leonardo, Martino, Piera Anna, Dallavalle, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979754/
https://www.ncbi.nlm.nih.gov/pubmed/27559415
http://dx.doi.org/10.3762/bjoc.12.159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979754/
https://www.ncbi.nlm.nih.gov/pubmed/27559415
http://dx.doi.org/10.3762/bjoc.12.159

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