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Flow carbonylation of sterically hindered ortho-substituted iodoarenes

The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide...

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Detalles Bibliográficos
Autores principales: Mallia, Carl J, Walter, Gary C, Baxendale, Ian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979912/
https://www.ncbi.nlm.nih.gov/pubmed/27559403
http://dx.doi.org/10.3762/bjoc.12.147
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author Mallia, Carl J
Walter, Gary C
Baxendale, Ian R
author_facet Mallia, Carl J
Walter, Gary C
Baxendale, Ian R
author_sort Mallia, Carl J
collection PubMed
description The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.
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spelling pubmed-49799122016-08-24 Flow carbonylation of sterically hindered ortho-substituted iodoarenes Mallia, Carl J Walter, Gary C Baxendale, Ian R Beilstein J Org Chem Full Research Paper The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions. Beilstein-Institut 2016-07-19 /pmc/articles/PMC4979912/ /pubmed/27559403 http://dx.doi.org/10.3762/bjoc.12.147 Text en Copyright © 2016, Mallia et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Mallia, Carl J
Walter, Gary C
Baxendale, Ian R
Flow carbonylation of sterically hindered ortho-substituted iodoarenes
title Flow carbonylation of sterically hindered ortho-substituted iodoarenes
title_full Flow carbonylation of sterically hindered ortho-substituted iodoarenes
title_fullStr Flow carbonylation of sterically hindered ortho-substituted iodoarenes
title_full_unstemmed Flow carbonylation of sterically hindered ortho-substituted iodoarenes
title_short Flow carbonylation of sterically hindered ortho-substituted iodoarenes
title_sort flow carbonylation of sterically hindered ortho-substituted iodoarenes
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979912/
https://www.ncbi.nlm.nih.gov/pubmed/27559403
http://dx.doi.org/10.3762/bjoc.12.147
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