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Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis

IκBβis an inhibitor of nuclear factor kappa B(NF-κB) and participates in the cardiac response to sepsis. However, the role of the hypo-phosphorylated form of IκBβ at Ser313, which can be detected during sepsis, is unknown. Here, we examined the effects of IκBβ with a mutation at Ser313→Ala313 on car...

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Detalles Bibliográficos
Autores principales: Wang, Guang-Qing, Tang, Tao, Wang, Zhong-Shan, Liu, Ying-Ying, Wang, Li, Luo, Peng-Fei, Xia, Zhao-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979969/
https://www.ncbi.nlm.nih.gov/pubmed/27508931
http://dx.doi.org/10.1371/journal.pone.0160860