Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity

Microtubules play critical roles in vital cell processes, including cell growth, division, and migration. Microtubule-targeting small molecules are chemotherapeutic agents that are widely used in the treatment of cancer. Many of these compounds are structurally complex natural products (e.g., paclit...

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Detalles Bibliográficos
Autores principales: Magalhaes, Luma G., Marques, Fernando B., da Fonseca, Marina B., Rogério, Kamilla R., Graebin, Cedric S., Andricopulo, Adriano D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980028/
https://www.ncbi.nlm.nih.gov/pubmed/27508497
http://dx.doi.org/10.1371/journal.pone.0160842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980028/
https://www.ncbi.nlm.nih.gov/pubmed/27508497
http://dx.doi.org/10.1371/journal.pone.0160842

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