Cargando…

Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection

The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nogueira, Paula M., Assis, Rafael R., Torrecilhas, Ana C., Saraiva, Elvira M., Pessoa, Natália L., Campos, Marco A., Marialva, Eric F., Ríos-Velasquez, Cláudia M., Pessoa, Felipe A., Secundino, Nágila F., Rugani, Jerônimo N., Nieves, Elsa, Turco, Salvatore J., Melo, Maria N., Soares, Rodrigo P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980043/ https://www.ncbi.nlm.nih.gov/pubmed/27508930 http://dx.doi.org/10.1371/journal.pntd.0004848

Ejemplares similares

Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
por: Nogueira, Paula M., et al.
Publicado: (2017)

Two biochemically distinct lipophosphoglycans from Leishmania braziliensis and Leishmania infantum trigger different innate immune responses in murine macrophages
por: Ibraim, Izabela Coimbra, et al.
Publicado: (2013)

Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs
por: Rêgo, Felipe D., et al.
Publicado: (2022)

Leishmania enriettii: biochemical characterisation of lipophosphoglycans (LPGs) and glycoinositolphospholipids (GIPLs) and infectivity to Cavia porcellus
por: Paranaíba, Larissa Ferreira, et al.
Publicado: (2015)

Lutzomyia umbratilis from an area south of the Negro River is refractory to in vitro interaction with Leishmania guyanensis
por: Soares, Rodrigo Pedro, et al.
Publicado: (2018)

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome
por: de Carvalho, Renan V.H., et al.
Publicado: (2019)

Leishmania major Survival in Selective Phlebotomus papatasi Sand Fly Vector Requires a Specific SCG-Encoded Lipophosphoglycan Galactosylation Pattern
por: Dobson, Deborah E., et al.
Publicado: (2010)

Intraspecies Polymorphisms in the Lipophosphoglycan of L. braziliensis Differentially Modulate Macrophage Activation via TLR4
por: Vieira, Tamara da Silva, et al.
Publicado: (2019)

Binding of Leishmania infantum Lipophosphoglycan to the Midgut Is Not Sufficient To Define Vector Competence in Lutzomyia longipalpis Sand Flies
por: Coutinho-Abreu, Iliano V., et al.
Publicado: (2020)

Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan
por: Desjardins, Michel, et al.
Publicado: (1997)

The Leishmania donovani Lipophosphoglycan Excludes the Vesicular Proton-ATPase from Phagosomes by Impairing the Recruitment of Synaptotagmin V
por: Vinet, Adrien F., et al.
Publicado: (2009)

Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promote Disease Progression and Induce the Production of Different Cytokines in Macrophages and B-1 Cells
por: Barbosa, Fernanda Marins Costa, et al.
Publicado: (2018)

Differential Midgut Attachment of Leishmania (Viannia) braziliensis in the Sand Flies Lutzomyia (Nyssomyia) whitmani and Lutzomyia (Nyssomyia) intermedia
por: Soares, Rodrigo P., et al.
Publicado: (2010)

Lipophosphoglycan From Dermotropic New World Leishmania Upregulates Interleukin-32 and Proinflammatory Cytokines Through TLR4 and NOD2 Receptors
por: Silveira, Murilo Barros, et al.
Publicado: (2022)

Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2 (−)) but Not Lipophosphoglycan (lpg1 (−)) for Survival in Permissive Sand Fly Vectors
por: Svárovská, Anna, et al.
Publicado: (2010)

Leishmania infantum Defective in Lipophosphoglycan Biosynthesis Interferes With Activation of Human Neutrophils
por: Quintela-Carvalho, Graziele, et al.
Publicado: (2022)

Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan
Publicado: (1995)

Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan
por: Franco, Luis H., et al.
Publicado: (2012)

Endocytosis and Exocytosis in Leishmania amazonensis Are Modulated by Bromoenol Lactone
por: Fernandes, Anne C. S., et al.
Publicado: (2020)

Sphingolipid Degradation in Leishmania (Leishmania) amazonensis
por: Pillai, Agiesh Balakrishna, et al.
Publicado: (2012)

Leishmania infantum-derived lipophosphoglycan as an antigen in the accurate serodiagnosis of canine leishmaniasis
por: Portela, Ricardo Dias, et al.
Publicado: (2019)

Morphological aspects of immature stages of Migonemyia migonei (Diptera: Psychodidae, Phlebotominae), an important vector of Leishmaniosis in South America, described by scanning electron microscopy
por: Marialva, Eric Fabrício, et al.
Publicado: (2020)

Cell-to-cell transfer of Leishmania amazonensis amastigotes is mediated by immunomodulatory LAMP-rich parasitophorous extrusions
por: Real, Fernando, et al.
Publicado: (2014)

A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan
por: Amprey, Joseph L., et al.
Publicado: (2004)

The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
por: Tschoeke, Diogo A, et al.
Publicado: (2014)

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes
por: Balanco, José Mário F., et al.
Publicado: (2019)

Predominance of Leishmania (Leishmania) amazonensis DNA in Lutzomyia longipalpis sand flies (Diptera: Psychodidae) from an endemic area for leishmaniasis in Northeastern Brazil
por: Carvalho-Silva, Reyllane, et al.
Publicado: (2022)

Optimization of DNA Extraction from Individual Sand Flies for PCR Amplification
por: Caligiuri, Lorena G., et al.
Publicado: (2019)

Infection Parameters in the Sand Fly Vector That Predict Transmission of Leishmania major
por: Stamper, Lisa W., et al.
Publicado: (2011)

Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromolar Affinity
por: Martins, Thaís Viana Fialho, et al.
Publicado: (2018)

Proteins involved in the biosynthesis of lipophosphoglycan in Leishmania: a comparative genomic and evolutionary analysis
por: Azevedo, Lucas Gentil, et al.
Publicado: (2020)

Leishmania amazonensis Promastigotes or Extracellular Vesicles Modulate B-1 Cell Activation and Differentiation
por: Reis, Natasha Ferraz de Campos, et al.
Publicado: (2020)

Osteopontin in the host response to Leishmania amazonensis
por: Giraud, Emilie, et al.
Publicado: (2019)

In Vitro and In Vivo Activity of a Palladacycle Complex on Leishmania (Leishmania) amazonensis
por: Paladi, Carolina de Siqueira, et al.
Publicado: (2012)

Effect of 3-Carene and the Micellar Formulation on Leishmania (Leishmania) amazonensis
por: Silva, Audrey Rouse Soares Tavares, et al.
Publicado: (2023)

Leishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?
por: Forestier, Claire-Lise, et al.
Publicado: (2015)

Antileishmanial and Immunomodulatory Effect of Babassu-Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection
por: da Silva, Mayara Cristina Pinto, et al.
Publicado: (2018)

Phenotypical Differences between Leishmania (Leishmania) amazonensis PH8 and LV79 Strains May Impact Survival in Mammal Host and in Phlebotomine Sand Flies
por: Tano, Fabia Tomie, et al.
Publicado: (2023)

Leishmania infantum Lipophosphoglycan-Deficient Mutants: A Tool to Study Host Cell-Parasite Interplay
por: Lázaro-Souza, Milena, et al.
Publicado: (2018)

Lipophosphoglycans from dermotropic Leishmania infantum are more pro-inflammatory than those from viscerotropic strains
por: Cardoso, Camila A, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gm852jc3tj7oddg7kmpqbt4ngl