A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease

In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify a...

Descripción completa

Detalles Bibliográficos
Autores principales: Freer, Rosie, Sormanni, Pietro, Vecchi, Giulia, Ciryam, Prajwal, Dobson, Christopher M., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980108/
https://www.ncbi.nlm.nih.gov/pubmed/27532054
http://dx.doi.org/10.1126/sciadv.1600947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980108/
https://www.ncbi.nlm.nih.gov/pubmed/27532054
http://dx.doi.org/10.1126/sciadv.1600947

Ejemplares similares