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A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
In Alzheimer’s disease, aggregates of Aβ and tau in amyloid plaques and neurofibrillary tangles spread progressively across brain tissues following a characteristic pattern, implying a tissue-specific vulnerability to the disease. We report a transcriptional analysis of healthy brains and identify a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980108/ https://www.ncbi.nlm.nih.gov/pubmed/27532054 http://dx.doi.org/10.1126/sciadv.1600947 |