N-end rule pathway inhibition assists colon tumor regression via necroptosis

Recent study has shown that N-end rule pathway, an ubiquitin dependent proteolytic system, counteracts cell death by degrading many antisurvival protein fragments like BCL(xL), BRCA1, RIPK1, etc. Inhibition of the N-end rule pathway can lead to metabolic stabilization of proapoptotic protein fragmen...

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Detalles Bibliográficos
Autores principales: Agarwalla, Pritha, Banerjee, Rajkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980110/
https://www.ncbi.nlm.nih.gov/pubmed/27556106
http://dx.doi.org/10.1038/mto.2016.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980110/
https://www.ncbi.nlm.nih.gov/pubmed/27556106
http://dx.doi.org/10.1038/mto.2016.20

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