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Notch-1 signaling promotes the cyclinD1-dependent generation of mammary tumor-initiating cells which can revert to bi-potential progenitors from which they arise
In a previous work, we reported that young transgenic (Tg) mice expressing the intracellular domain of Notch1 (N1(IC)) showed expansion of lin(−) CD24(+) CD29(high) mammary cells enriched for stem cells and later developed mammary tumors. Mammary tumor formation was abolished or greatly reduced in c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980122/ https://www.ncbi.nlm.nih.gov/pubmed/22907433 http://dx.doi.org/10.1038/onc.2012.341 |