KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia

Overexpression in humans of KCNH2-3.1, which encodes a primate-specific and brain-selective isoform of the human ether-a-go-go-related (hERG) potassium channel, is associated with impaired cognition, inefficient neural processing, and schizophrenia. Here, we describe a new mouse model that incorpora...

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Detalles Bibliográficos
Autores principales: Carr, Gregory V., Chen, Jingshan, Yang, Feng, Ren, Ming, Yuan, Peixiong, Tian, Qingjun, Bebensee, Audrey, Zhang, Grace Y., Du, Jing, Glineburg, Paul, Xun, Randy, Akhile, Omoye, Akuma, Daniel, Pickel, James, Barrow, James C., Papaleo, Francesco, Weinberger, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980295/
https://www.ncbi.nlm.nih.gov/pubmed/26857598
http://dx.doi.org/10.1038/mp.2015.219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980295/
https://www.ncbi.nlm.nih.gov/pubmed/26857598
http://dx.doi.org/10.1038/mp.2015.219

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