Cargando…

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

Replisome assembly at eukaryotic replication forks connects the DNA helicase to DNA polymerases and many other factors. The helicase binds the leading-strand polymerase directly, but is connected to the Pol α lagging-strand polymerase by the trimeric adaptor Ctf4. Here, we identify new Ctf4 partners...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villa, Fabrizio, Simon, Aline C., Ortiz Bazan, Maria Angeles, Kilkenny, Mairi L., Wirthensohn, David, Wightman, Mel, Matak-Vinkovíc, Dijana, Pellegrini, Luca, Labib, Karim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980431/ https://www.ncbi.nlm.nih.gov/pubmed/27397685 http://dx.doi.org/10.1016/j.molcel.2016.06.009

Ejemplares similares

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
por: Simon, Aline C., et al.
Publicado: (2014)

The eukaryotic CMG helicase pumpjack and integration into the replisome
por: Sun, Jingchuan, et al.
Publicado: (2016)

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
por: Costa, Alessandro, et al.
Publicado: (2014)

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome
por: Eickhoff, Patrik, et al.
Publicado: (2019)

Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase
por: Maculins, Timurs, et al.
Publicado: (2015)

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
por: Deegan, Tom D, et al.
Publicado: (2020)

A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome
por: Kilkenny, Mairi L., et al.
Publicado: (2012)

Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
por: Xiang, Shengyan, et al.
Publicado: (2023)

Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes
por: Polasek-Sedlackova, Hana, et al.
Publicado: (2022)

Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome
por: Oki, Keisuke, et al.
Publicado: (2021)

Structure of the eukaryotic replicative CMG helicase and pumpjack motion
por: Yuan, Zuanning, et al.
Publicado: (2016)

DNA unwinding mechanism of a eukaryotic replicative CMG helicase
por: Yuan, Zuanning, et al.
Publicado: (2020)

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
por: Goswami, Panchali, et al.
Publicado: (2018)

The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box
por: Kilkenny, Mairi L., et al.
Publicado: (2017)

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin
por: Holzer, Sandro, et al.
Publicado: (2017)

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin
por: Holzer, Sandro, et al.
Publicado: (2020)

DONSON is required for CMG helicase assembly in the mammalian cell cycle
por: Evrin, Cecile, et al.
Publicado: (2023)

Structure of human Cdc45 and implications for CMG helicase function
por: Simon, Aline C., et al.
Publicado: (2016)

Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome
por: Samora, Catarina P., et al.
Publicado: (2016)

A conserved mechanism for regulating replisome disassembly in eukaryotes
por: Jenkyn-Bedford, Michael, et al.
Publicado: (2021)

Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
por: Langston, Lance, et al.
Publicado: (2017)

Mechanisms of eukaryotic replisome disassembly
por: Moreno, Sara Priego, et al.
Publicado: (2020)

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast
por: Mukherjee, Progya P., et al.
Publicado: (2019)

Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer
por: Reed, Damon R., et al.
Publicado: (2020)

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks
por: Langston, Lance D, et al.
Publicado: (2017)

Histone H2A‐H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin
por: Evrin, Cecile, et al.
Publicado: (2018)

Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes
por: Le, Thanh Thi, et al.
Publicado: (2021)

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication
por: Maric, Marija, et al.
Publicado: (2017)

Mechanism of replication origin melting nucleated by CMG helicase assembly
por: Lewis, Jacob S., et al.
Publicado: (2022)

DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans
por: Xia, Yisui, et al.
Publicado: (2023)

CUL2(LRR1), TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle
por: Villa, Fabrizio, et al.
Publicado: (2021)

Ctf4 organizes sister replisomes and Pol α into a replication factory
por: Yuan, Zuanning, et al.
Publicado: (2019)

CryoEM structures of human CMG–ATPγS–DNA and CMG–AND-1 complexes
por: Rzechorzek, Neil J, et al.
Publicado: (2020)

The Initial Response of a Eukaryotic Replisome to DNA Damage
por: Taylor, Martin R.G., et al.
Publicado: (2018)

The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy
por: Seo, Yeon-Soo, et al.
Publicado: (2018)

Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases
por: Nepon-Sixt, Brook S., et al.
Publicado: (2019)

DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier
por: Hizume, Kohji, et al.
Publicado: (2018)

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase
por: Lõoke, Marko, et al.
Publicado: (2017)

Synergism between CMG helicase and leading strand DNA polymerase at replication fork
por: Xu, Zhichun, et al.
Publicado: (2023)

Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication
por: Atkinson, John, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_3ajg1fffhg5drluts1tf736ric