Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling

The poly(ADP-ribose) polymerase (PARP) Tankyrase (TNKS and TNKS2) is paramount to Wnt-β-catenin signaling and a promising therapeutic target in Wnt-dependent cancers. The pool of active β-catenin is normally limited by destruction complexes, whose assembly depends on the polymeric master scaffolding...

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Detalles Bibliográficos
Autores principales: Mariotti, Laura, Templeton, Catherine M., Ranes, Michael, Paracuellos, Patricia, Cronin, Nora, Beuron, Fabienne, Morris, Edward, Guettler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980433/
https://www.ncbi.nlm.nih.gov/pubmed/27494558
http://dx.doi.org/10.1016/j.molcel.2016.06.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980433/
https://www.ncbi.nlm.nih.gov/pubmed/27494558
http://dx.doi.org/10.1016/j.molcel.2016.06.019

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