Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency

Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment opti...

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Detalles Bibliográficos
Autores principales: Ehinger, Johannes K., Piel, Sarah, Ford, Rhonan, Karlsson, Michael, Sjövall, Fredrik, Frostner, Eleonor Åsander, Morota, Saori, Taylor, Robert W., Turnbull, Doug M., Cornell, Clive, Moss, Steven J., Metzsch, Carsten, Hansson, Magnus J., Fliri, Hans, Elmér, Eskil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980488/
https://www.ncbi.nlm.nih.gov/pubmed/27502960
http://dx.doi.org/10.1038/ncomms12317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980488/
https://www.ncbi.nlm.nih.gov/pubmed/27502960
http://dx.doi.org/10.1038/ncomms12317

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