The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer’s disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory...

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Detalles Bibliográficos
Autores principales: Batalha, Vânia L., Ferreira, Diana G., Coelho, Joana E., Valadas, Jorge S., Gomes, Rui, Temido-Ferreira, Mariana, Shmidt, Tatiana, Baqi, Younis, Buée, Luc, Müller, Christa E., Hamdane, Malika, Outeiro, Tiago F., Bader, Michael, Meijsing, Sebastiaan H., Sadri-Vakili, Ghazaleh, Blum, David, Lopes, Luísa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980603/
https://www.ncbi.nlm.nih.gov/pubmed/27510168
http://dx.doi.org/10.1038/srep31493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980603/
https://www.ncbi.nlm.nih.gov/pubmed/27510168
http://dx.doi.org/10.1038/srep31493

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