A Novel Nitrobenzoate Microtubule Inhibitor that Overcomes Multidrug Resistance Exhibits Antitumor Activity

Multidrug resistance is a major limitation for microtubule-binding agents in cancer treatment. Here we report a novel microtubule inhibitor (2-morpholin-4-yl-5-nitro-benzoic acid 4-methylsulfanyl-benzyl ester, IMB5046), its cytotoxicity against multidrug-resistant cell lines and its antitumor effica...

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Detalles Bibliográficos
Autores principales: Zheng, Yan-Bo, Gong, Jian-Hua, Liu, Xiu-Jun, Wu, Shu-Ying, Li, Yi, Xu, Xian-Dong, Shang, Bo-Yang, Zhou, Jin-Ming, Zhu, Zhi-Ling, Si, Shu-Yi, Zhen, Yong-Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980604/
https://www.ncbi.nlm.nih.gov/pubmed/27510727
http://dx.doi.org/10.1038/srep31472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980604/
https://www.ncbi.nlm.nih.gov/pubmed/27510727
http://dx.doi.org/10.1038/srep31472

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