Localized Down-regulation of P-glycoprotein by Focused Ultrasound and Microbubbles induced Blood-Brain Barrier Disruption in Rat Brain

Multi-drug resistant efflux transporters found in Blood-Brain Barrier (BBB) acts as a functional barrier, by pumping out most of the drugs into the blood. Previous studies showed focused ultrasound (FUS) induced microbubble oscillation can disrupt the BBB by loosening the tight junctions in the brai...

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Detalles Bibliográficos
Autores principales: Cho, HongSeok, Lee, Hwa-Youn, Han, Mun, Choi, Jong-ryul, Ahn, Sanghyun, Lee, Taekwan, Chang, Yongmin, Park, Juyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980618/
https://www.ncbi.nlm.nih.gov/pubmed/27510760
http://dx.doi.org/10.1038/srep31201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980618/
https://www.ncbi.nlm.nih.gov/pubmed/27510760
http://dx.doi.org/10.1038/srep31201

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