N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

Influenza virus PA endonuclease has recently emerged as an attractive target for the development of novel antiviral therapeutics. This is an enzyme with divalent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive strategy to inhibit enzymatic a...

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Detalles Bibliográficos
Autores principales: Carcelli, Mauro, Rogolino, Dominga, Gatti, Anna, De Luca, Laura, Sechi, Mario, Kumar, Gyanendra, White, Stephen W., Stevaert, Annelies, Naesens, Lieve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980666/
https://www.ncbi.nlm.nih.gov/pubmed/27510745
http://dx.doi.org/10.1038/srep31500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980666/
https://www.ncbi.nlm.nih.gov/pubmed/27510745
http://dx.doi.org/10.1038/srep31500

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